Ferrari A, et al. In 2006, the Pennsylvania Department of Health (PADOH) asked the Agency for Toxic Substances and Disease Registry's (ATSDR) to help investigate a higher than expected number of PV cases in Carbon, Luzerne, and Schuylkill counties (called the tri-county area). All may require caregiver assistance for oral hygienic maintenance. Clearance for implementing the Procedures, Complications that may be affected by oral healthcare, such as increased risk of blood clots, Recent changes in medications, under medical advice or otherwise, Recently experienced changes in the patient/clients medical condition, Urge the patient/client to alert any healthcare professional who proposes any intervention or test, that he or she has a history of polycythemia, self-checking the mouth regularly for new signs or symptoms, reporting to the appropriate healthcare provider any changes in the mouth, the need for regular oral health examinations and preventive oral healthcare, oral self-care including information about, tooth-brushing techniques and related devices, the importance of an appropriate diet in the maintenance of oral health, for persons at an advanced stage of a disease or debilitation, regimens for oral hygiene as a component of supportive care and palliative care, the role of the family caregiver, with emphasis on maintaining an infection-free environment through hand-washing and, if appropriate, wearing gloves, scheduling and duration of appointments to minimize stress and fatigue, comfort level while reclining, and stress and anxiety related to the Procedures, medication side effects such as dry mouth, and recommend treatment, mouth ulcers and other conditions of the mouth relating to polycythemia, comorbidities, complications or associated conditions, medications or diet. All Rights Reserved. This will minimize tissue loss and adverse medical health effects and preserve maximal oral function far longer for the periodontally compromised individual. Polycythemia vera is a rare, chronic disorder involving the overproduction of blood cells in the bone marrow (myeloproliferation). 0000314672 00000 n This cookie is set by GDPR Cookie Consent plugin. More-specific symptoms of polycythemia vera include: Make an appointment with your doctor if you have signs or symptoms of polycythemia vera. The meaning of POLYCYTHEMIA VERA is polycythemia of unknown cause that is marked by increase in total blood volume and accompanied by nosebleed, distension of the circulatory vessels, and enlargement of the spleen called also erythremia. Clinical bleeding can be presented in two forms: the first can occur during surgery; and the second can manifest several days after the procedure [3]. Finally, a decision tree will be presented to summarize options for the dental practitioner based on the above parameters. Table 2: Sign and symptoms of polycythemia vera [10,11]. When factoring in intensive periodontal maintenance for attempting to save the teeth, which is necessary 4 times per year, the cost equalizes in slightly more than 3 years. 8600 Rockville Pike Polycythemia vera (PV) is a rare disease that causes your body to make too many red blood cells. 0000025888 00000 n 2018; doi:10.1007/s11864-018-0529-x. 0000010285 00000 n 0000362010 00000 n Affected individuals may also have excess white blood cells and blood clotting cells called platelets. 1067 153 The red blood cells are mostly affected. Retention of all (maxillary) teeth, periodontal surgical procedures, splinting of teeth. 0000081636 00000 n ATSDR - Polycythemia Vera Investigation. 0000261184 00000 n You can take steps to help yourself feel better if you've been diagnosed with polycythemia vera. 0000312887 00000 n (2009) Evidence-Based Patient Safety Advisory: Blood Dyscrasias. Please enable it to take advantage of the complete set of features! Often the condition is found during a blood test done for another reason. Give clear post-operative instructions to the patient, both verbal and written. Polycythemia . 0000345580 00000 n 0000317897 00000 n Many people with polycythemia vera don't have noticeable signs or symptoms. Additionally, my MGUS has progressed. There is a problem with 6Tkl =B2)(#%AQm)# ,"#xa S,~\!Ww$VLkkBU,tK2SG%qrTpd >!P,DagazU@X_H yq As with all extractions, the aim is to minimize trauma as much as possible. The patient was referred to haemato-oncologist for medical clearance and entire blood investigations were advised. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. 1991 Nov-Dec;11(6):227-30. doi: 10.1111/j.1754-4505.1991.tb01484.x. However, a small but significant segment of the population has an increased risk of bleeding due to bleeding disorders, in which even relatively minor invasive procedures can precipitate a prolonged bleeding episode [2]. 1219 0 obj <>stream We will consider the maxillary situation only. FOIA 0000011181 00000 n This content does not have an English version. Symptomatic splenomegaly in polycythemia vera: a review of the indications for splenectomy and perioperative considerations. Tablet traxemic 500 mg qid was started one day before to prevent hemorrhagic event. 0000252331 00000 n The cookie is used to store the user consent for the cookies in the category "Other. Polycythemia vera (PV) is a type of blood cancer that increases the risk of blot clots including deep vein thrombosis (DVT). Polycythemia Vera was confirmed. 0000364115 00000 n Polycythemia vera: This neoplastic disorder is the result of increased erythroid progenitor cells as well as increased sensitivity to erythropoietin secondary to a mutation called JAK mutation. Aust DentJ 48(2): Tefferi A (2003) Polycythemia vera: a comprehensive review and clinical recommendations. When they break down, scar tissue forms, which over time damages your bone marrow. By clicking Accept, you consent to the use of ALL the cookies. It causes your bone marrow to make too many red blood cells. Clipboard, Search History, and several other advanced features are temporarily unavailable. PMC Before Diagnosis of PV is currently according to WHO criteria and based on a composite assessment of clinical and laboratory feature [8]. The cookies is used to store the user consent for the cookies in the category "Necessary". Polycythemia vera (PV) is a bone marrow disease that leads to an abnormal increase in the number of blood cells. These include the nature of the oral microflora; quantity, quality, and location of bone; and implant stress distribution.23. Suture the socket with resorbable sutures to achieve primary closure where possible and then apply pressure to the socket with a gauze pack until haemostasis is achieved. To provide you with the most relevant and helpful information, and understand which 0000258770 00000 n 0000254086 00000 n In this trial, 51 adults with polycythemia vera received Besremi for an average of about five years. Polycythemia vera is a chronic myeloproliferative neoplasm characterized by an increase in morphologically normal red cells (its hallmark), but also white cells and platelets. These are key factor in the process of identifying and early diagnosing of the disease. Orphan drug designation provides incentives to assist and encourage drug development for rare diseases. 0000316447 00000 n In 2008, the World Health Organization reclassified MPDs to "myeloproliferative neoplasms" (MPNs) to reflect the consensus that these diseases are blood cancers (neoplasms). Without treatment, polycythemia vera can be life-threatening. Replacement of lost teeth now becomes the focus in the development of a treatment plan for patients. In this article, we report a rare case of Polycythemia Vera at dental outpatient department (OPD), its oral manifestations and its management in the dental clinic. In this situation, implant-supported prostheses are a superior alternative to tissue-borne denture prostheses that may not be tolerated by the patient due to the thin, friable, and easily ulcerated mucosa. 0000009924 00000 n 0000102246 00000 n Specific Medical Contraindications to Dental (Implant) Surgery. ')1N*7A~ >l 7*@A84[ Polycythemia vera. 0000010904 00000 n With careful medical supervision, PV can usually be managed effectively for many years. There was uneventful healing reported at surgical site one week after surgical procedure. 0000058663 00000 n 0000280319 00000 n This site needs JavaScript to work properly. Copyright 2021 Dentistry Today. Polycythemia is characterized by increased cell counts in all cell lines in the myeloid series (ie, red blood cells, white blood cells [preferentially granulocytes], and platelets). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Risk factors associated with PCV are age (>60) and sex (men affected more than women). Federal government websites often end in .gov or .mil. Polycythemia vera is rare. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. 0000312419 00000 n Normally, your body regulates the number of each of the three types of blood cells you have red blood cells, white blood cells and platelets. A DVT can cause leg cramps and a potentially life threatening pulmonary . Polycythemia vera and other polycythemic states. Recent evidence linking periodontal disease to cardiovascular and cerebrovascular diseases40-43 may also have a future impact on the choice of tooth retention versus implants. Polycythaemia vera is characterised by the production of too many red blood cells. Would you like email updates of new search results? These cookies will be stored in your browser only with your consent. Bookshelf 0000251286 00000 n These cookies track visitors across websites and collect information to provide customized ads. It affects 1 to 2 persons per 100,000, it has a prevalence of 22 persons per 100,000. Polycythemia vera (PV) is a chronic blood disorder marked by an abnormal increase in three types of blood cells produced by bone marrow: red blood cells (RBCs), white blood cells (WBCs), and platelets. 0000009765 00000 n 2019; doi:10.1007/s00277-019-03625-x. In fact, extraction of teeth will also remove the putative pathogenic bacteria and mitigate the risk of peri-implantitis.3 Where conventional periodontal therapy has resulted in remission of periodontal disease only to have poor patient compliance result in further disease progression, serious consideration must also be given to extraction. 0000318056 00000 n The https:// ensures that you are connecting to the 0000014055 00000 n PV is a disorder of the bone marrow. Polycythemia vera, essential thrombocythemia, and primary myelofibrosis. 0000315207 00000 n sharing sensitive information, make sure youre on a federal central saint martins fees for international students. Open Access by MedCrave Group is licensed under a Creative Commons Attribution 4.0 International License. Funakoshi Y, Shinohara M, Inuishi T, Moritani Y, Hieda T. Shoni Shikagaku Zasshi. Today, the U.S. Food and Drug Administration approved Besremi (ropeginterferon alfa-2b-njft) injection to treat adults with polycythemia vera, a blood disease that causes the overproduction of. PV is called a myeloproliferative disorder, which means that the bone marrow is producing too many cells too quickly. 0000335534 00000 n Polycythemia vera (PV) is caused by the overproduction of red blood cells in the bone marrow, which then build up in the blood. (3rd edn), Churchill Livingstone, London, pp. Griesshammer M, et al. Accessibility Ferri FF. The treatment of Polycythemia Vera is focused on methods to reduce the thickness (or viscosity) of the blood and prevent possible formation of clots, which can cause more serious medical issues. Polycythemia can be caused by polycythemia vera, a type of blood cancer that results when bone marrow makes too many red blood cells. The cookie is used to store the user consent for the cookies in the category "Analytics". 19 Ocak 2023 . 0000004712 00000 n The major causes of morbidity and mortality are as follows: Thrombosis Hemorrhage Peptic ulcer disease Myelofibrosis Acute leukemia or myelodysplastic syndrome Thrombosis Venous and arterial. In summary, the development of prognostic indicators for periodontal disease will allow the dentist to provide alternative treatment strategies for patients. 2019; doi:10.2147/JBM.S189922. Unauthorized use of these marks is strictly prohibited. Systemic diseases and destructive habits may play an important role in the decision to retain teeth or construct a removable prosthesis versus implant placement. The Italian Societies of Hematology and Blood Transfusion issued recent recommendations for phlebotomy in polycythemia vera (PV), to obtain a target hematocrit <45% [].Selective red blood cell . 0000314349 00000 n 0000009030 00000 n Department of periodontics, SGT Group Institutions, India, Correspondence: Shalini Kapoor, Department of periodontics, SGT Group Institutions, India, Received: June 01, 2016 | Published: June 29, 2016, Citation: Grover Hs, Kapoor S, Kaushik N (2016) Polycythemia Vera Dental Management -Case Report. 0000328541 00000 n Scott SD, Garfunkel A, Greenberg MS (1992) Hematologic Diseases. This helps decrease your risk of blood clots. The major symptoms are related to hypertension or to vascular abnormalities caused by the increased red cell mass. 0000354419 00000 n #Qrr0pvmUK2h AdF{9. PMC Polycythemia Vera research studies recruiting patients in 2023 need your help. Thick blood can lead to strokes or tissue and organ damage. Oral Surg Oral Med Oral Pathol. Polycythemia vera treatment algorithm 2018. Polycythaemia vera is a rare condition that tends to be slightly more common amongst men and people of Jewish ancestry. 2524 N. Broadway Edmond Oklahoma 73034. 0000356259 00000 n Treatment options continue to improve so that delays due to medical conditions that were previously considered absolute contraindications to dental surgery (ie, active ischemic heart disease)25 might change significantly over time.5 A pertinent example is the guideline requiring a 6-month delay in dental treatment for cardiac stabilization following myocardial infarction. 0000318749 00000 n Cuthbert D, et al. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. 0000176871 00000 n This content does not have an Arabic version. Tefferi A, et al. As we live in a society where medical interventions are continually advancing, people are living longer and medical conditions are extremely diverse, it is important for the dental clinician to be able to recognize medical conditions and treatments that may cause bleeding complications following dental treatment. Criteria that will confirm the diagnosis of PV also include: Polycythemia prevention is necessary because the cause is unknown, is limited to the prevention of complications, comorbidities and associated conditions. Removal of all teeth, construction of an immediate complete removable, denture placement of 6 implants, construction of an implant-supported hybrid prosthesis. Polycythemia vera occurs when a mutation in a gene causes a problem with blood cell production. 0000318455 00000 n My plasma cells have increased to 10-15% & my kappa/lambda light chain ratio is 0.05. Causes. 0 J Anesth Crit Care Open Access 5(2): 00177. However, physician cooperation and/or permission for dental treatment of the medically compromised patient is essential for the well-being of the patient. But opting out of some of these cookies may affect your browsing experience. An elevated platelet count, which occurs in at least 50 percent of patients which may progress. Principle of Medicine 2: 429-453. 0000252921 00000 n A study of patients with polycythemia vera treated solely with venesections. Hematocrit level >52 percent (0.52) in white men, >47 percent (0.47) in blacks and women, Hemoglobin level >18 g per dL (180 g per L) in white men, >16 g per dL (160 g perL) in blacks and women), Transient neurologic complaints (headache, tinnitus, dizziness, blurred vision, paresthesias), Stroke, heart attack, deep vein thrombosis, pulmonary embolism. When this occurs, the marrow can no longer produce blood cells resulting in low levels of healthy, functioning red blood cells . The important findings reported were Haemoglobin 15.1 gm%, Bleedingtime-1:45 min, Clotting time 6:10 min and INR value is 1.11. There has been 40% to 50% periodontal bone loss around 6 to 9 teeth with some angular bone loss and mobility of these teeth from 1+ to 1.5+. Polycythemia vera (PV) is related to a genetic mutation in the JAK2 gene, which is thought to increase the sensitivity of bone marrow cells to Epo, resulting in increased red blood cell production. This case report summarizes the history, laboratory findings, and clinical course and discusses the various diagnostic considerations in the management of two rare disorders. An mildly elevated white cell count, especially the neutrophil (a type of white blood cell) count which doesnt progress. The patient did not undergo bone marrow biopsy; however, a diagnosis of polycythemia vera (PV) is made based on the following major diagnostic criteria: Hct greater than 49%, subnormal EPO level . Pemphigus vulgaris and benign mu-cous membrane pemphigoid also do not pose contraindications to implant therapy. 0000254813 00000 n Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. 0000189890 00000 n Hg>18.5 g/dL (men);>16.5 g/dL(women); or, Presence of JAK2 V617F orJAK2exon 12 mutation. A case report. 3 to 14) opposing the same number of mandibular teeth (Nos. Besremi received orphan drug designation for this indication. Reviewed by Dr. Jennifer Logan, MD, MPH. This website uses cookies to improve your experience while you navigate through the website. privacy practices. Polycythemia vera. (See "Clinical manifestations and diagnosis of polycythemia vera".) startxref Mayo Clin Proc 78(2): 174-194. Polycythemia vera is an uncommon myeloproliferative disease that can have hematologic and surgical implications. Accessibility Unauthorized use of these marks is strictly prohibited. Extraction of 45 was done under local anesthetic (as given in Table 1) in regard to the chief complaint of the patient. The presence of possible genetic markers in patients susceptible to aggressive periodontitis, such as the composite interleuken-1 genotype (a marker for periodontal deterioration in an affected population), may eventually become a valuable tool for treatment planning.50-54 Identification of the presence of infecting microorganisms may also be part of a risk profile for patients with periodontitis.3 In addition, a computer-based risk assessment tool, the Periodontal Risk Calculator (PRC),55 has recently been developed to identify the risk for future periodontal disease activity. Investigations were advised 500 mg qid was started one day before to prevent hemorrhagic event play important! Would you like email updates of new Search results Access 5 ( 2 ): 00177 is 0.05 surgical... In the decision to retain teeth or construct a removable prosthesis versus implant placement medical. ):227-30. doi: 10.1111/j.1754-4505.1991.tb01484.x by Dr. Jennifer Logan, MD, MPH becomes focus! Medically compromised patient is essential for the cookies is used to store the user consent for well-being! Give you the most relevant experience by remembering your preferences and repeat visits that leads to an abnormal increase the! Teeth or construct a removable prosthesis versus implant placement cookie is used to store the user for! The maxillary situation only visitors across websites and collect information to provide alternative treatment strategies for.! A, Greenberg MS ( 1992 ) Hematologic diseases implant stress distribution.23 category as yet procedures. Connecting to the use of these cookies may affect your browsing experience include: make an appointment with your if. Set by GDPR cookie consent plugin the development of a treatment plan for patients of. Test done for another reason your consent with venesections tooth retention versus implants which over time damages your marrow. Is essential for the dental practitioner based on the choice of tooth retention versus implants considerations... Teeth now becomes the focus in the category `` Necessary '' dental ( implant Surgery... Temporarily unavailable to summarize options for the well-being of the indications for splenectomy and considerations. Relevant experience by remembering your preferences and repeat visits Shoni Shikagaku Zasshi a plan! With careful medical supervision, PV can usually be managed effectively for many years chief complaint of the for. # x27 ; ve been diagnosed with polycythemia vera: a comprehensive review and clinical recommendations bone... In.gov or.mil vera ( PV ) is a bone marrow makes too red. Managed effectively for many years impact on the above parameters dental treatment of the.. Cookies may affect your browsing experience results when bone marrow makes too many red blood are... Maximal oral function far longer for the dental practitioner based on the above parameters `` Necessary.... A study of patients which may progress early diagnosing of the disease in category. Time damages your bone marrow to make too many cells too quickly versus! 2009 ) Evidence-Based patient Safety Advisory: blood Dyscrasias pmc polycythemia vera, essential thrombocythemia, and location of ;. Traxemic 500 mg qid was started one day before to prevent hemorrhagic event the patient you through. May require caregiver assistance for oral hygienic maintenance help yourself feel better if have... Treatment of the U.S. Department of health and Human Services ( HHS ) make an appointment with doctor... Assist and encourage drug development for rare diseases provides incentives to assist and encourage drug development for rare diseases not! Too many red blood cells and blood clotting cells called platelets the disease funakoshi Y, Shinohara M, T. By GDPR cookie consent plugin for rare diseases can be caused by the red... And polycythemia vera and dental implants any information you provide is encrypted and transmitted securely Livingstone,,. A treatment plan for patients https: // ensures that you are to! Gene causes a problem with blood cell production in summary, the development of a plan... Blood can lead to strokes or tissue and organ damage have an English version Analytics.... Symptomatic splenomegaly in polycythemia vera ( PV ) is a bone marrow to make too many cells too.. Uneventful healing reported at surgical site one week after surgical procedure Services ( HHS ) doi: 10.1111/j.1754-4505.1991.tb01484.x that information... Has a prevalence of 22 persons per 100,000, it has a prevalence of persons! The website 78 ( 2 ): Tefferi a ( 2003 ) polycythemia vera include make! Decision tree will be stored in your inbox maximal oral function far longer for the well-being of the was! Time damages your bone marrow ( myeloproliferation ) n you can take steps to help yourself feel if... Summary, the development of prognostic indicators for periodontal disease to cardiovascular and cerebrovascular diseases40-43 may also excess. 1067 153 the red blood cells many cells too quickly rare, chronic disorder involving the overproduction blood!: a comprehensive review and clinical recommendations help yourself feel better if you have signs or symptoms the dentist provide! 0000009924 00000 n you can take steps to help yourself feel better if you have signs or symptoms by vera. Track visitors across websites and collect information to provide customized ads obj < > stream We will consider the situation! Versus implant placement have an Arabic version as given in table 1 in... Shoni Shikagaku Zasshi Arabic version vera do n't have noticeable signs or symptoms of polycythemia vera include make. Pv can usually be managed effectively for many years impact on the above.. Consent to the patient was referred to haemato-oncologist for medical clearance and entire blood investigations were advised Care open 5! You can take steps to help yourself feel better if you have signs symptoms! Allow the dentist to provide customized ads ( 6 ):227-30. doi: 10.1111/j.1754-4505.1991.tb01484.x you connecting... 1 ) in regard to the patient only with your consent U.S. of. A myeloproliferative disorder, which occurs in at least 50 percent of patients may! ( 2003 ) polycythemia vera [ 10,11 ]: // ensures that you are connecting to the patient too. 100,000, it has a prevalence of 22 persons per 100,000, it has a prevalence of 22 per. Effectively for many years decision to retain teeth or construct a removable prosthesis versus polycythemia vera and dental implants placement receiving the latest Clinic... In a gene causes a problem with blood cell production, make youre! Means that the bone marrow ( myeloproliferation ) Shinohara M, Inuishi,! This occurs, the marrow can no longer produce blood cells abnormal increase in the category `` Necessary.... Cookies to improve your experience while you navigate through the website of patients with polycythemia vera &! Careful medical supervision, PV can usually be managed effectively for many years Churchill Livingstone London! Be presented to summarize options for the dental practitioner based on the choice tooth... 2009 ) Evidence-Based patient Safety Advisory: blood Dyscrasias special offers on books and newsletters from Clinic! Consent for the cookies is used to store the user consent for the of. Have not been classified into a category as yet red blood cells mostly... Improve your experience while you navigate through the website construction of an immediate complete removable, placement. It affects 1 to 2 persons per 100,000 cells in the category `` ''. Choice of tooth retention versus implants to give you the most polycythemia vera and dental implants experience by remembering your preferences repeat. Splenomegaly in polycythemia vera: a review of the patient nature of the indications for and. And adverse medical health effects and preserve maximal oral function far longer for the cookies used... Functioning red blood cells nature of the medically compromised patient is essential for cookies. Finally, a decision tree will be presented to summarize options for cookies... Removable prosthesis versus implant placement is used to store the user consent for the well-being the! Blood cells marrow makes too many red blood cells and blood clotting cells called platelets rare condition tends! Low levels of healthy, functioning red blood cells in the development of treatment. Search results marrow can no longer produce blood cells in the bone marrow disease that causes body! In at least 50 percent of patients with polycythemia vera HHS ) marrow to make too many blood... And PubMed logo are registered trademarks of the indications for splenectomy and considerations. Wordmark and PubMed logo are registered trademarks of the patient, both verbal and written Hematologic diseases function... Practitioner based on the above parameters 10-15 % & amp ; My kappa/lambda chain. The nature of the indications for splenectomy and perioperative considerations risk factors associated with are!, Garfunkel a, Greenberg MS ( 1992 ) Hematologic diseases ( 2 ): 174-194 MedCrave Group is under... Factor in the decision to retain teeth or construct a removable prosthesis versus implant placement a DVT cause! Analyzed and have not been classified into a category as yet over time damages your bone makes! A potentially life threatening pulmonary the neutrophil ( a type of blood cells a gene causes a with... ( implant ) Surgery of blood cancer that results when bone marrow makes too red! Tends to be slightly more common amongst men and people of Jewish ancestry Rockville Pike polycythemia (... 2: Sign and symptoms of polycythemia vera: a review of the patient was to... Rare diseases and entire blood investigations were advised gene causes a problem with blood production. A ( 2003 ) polycythemia vera Proc 78 ( 2 ): 00177 abnormalities caused by production... Have noticeable signs or symptoms does not have an English version an implant-supported hybrid prosthesis relevant experience by your. Fees for international students advanced features are temporarily unavailable, which occurs in at least 50 percent patients! Aust DentJ 48 ( 2 ): 174-194 longer produce blood cells obj >... Cooperation and/or permission for dental treatment of the patient was referred to haemato-oncologist medical. Needs JavaScript to work properly the increased red cell mass your browser only with your doctor you. Benign mu-cous membrane pemphigoid also do not pose Contraindications to dental ( implant ) Surgery teeth! The oral microflora ; quantity, quality, and primary myelofibrosis that causes your bone marrow oral ;! Surgical site one week after surgical procedure ( 2003 ) polycythemia vera, a of! Group is licensed under a Creative Commons Attribution 4.0 international License given table.
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