Taking it along with estrogen pills might reduce their effectiveness. Things to remember when you fill your prescription. 2008;47(2):605-12. doi:10.1002/hep.22044. MNT is the registered trade mark of Healthline Media. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. If you notice other effects not listed above, contact your doctor or pharmacist. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. It also looks at how to use milk thistle and whether there are any risks to consider. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Can you drink alcohol while taking milk thistle? Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. However, researchers theorize that it does. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Milk thistle had no effect on any of the drugs. Han YU, Guo D, Chen Y, et al. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. It is native to Mediterranean countries. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. Of the total drug interactions, It is possible to take too much milk thistle. The terms milk thistle and silymarin are often used interchangeably. Substances in milk thistle may reduce blood sugar. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. If it is near the time of the next dose, skip the missed dose. This document does not contain all possible interactions. Phytother Res. Dosage: How Much Milk Thistle Should I Take? However, consult a doctor to figure out the daily recommended dosage of this herb. Drs. It is lauded for its anti-inflammatory properties and several health benefits. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. Milk thistle is an herbal remedy with rich plant compounds. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Milk thistle may lower blood sugar levels in people with type 2 diabetes. milk thistle. You may report side effects to Health Canada at 1-866-234-2345. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. StatPearls Publishing; 2022. Consult your doctor before breast-feeding. More study is needed to confirm this. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. All rights reserved. Some people also call it Mary thistle and holy thistle. This herb is native to Southern Europe and is used widely for its benefits. 2007;2007(4):CD003620. 2018;9:1903. doi:10.3389/fimmu.2018.01903. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. 2014;2014:941085. doi:10.1155/2014/941085. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. Its not known whether milk thistle is helpful for other conditions. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. This publication is not copyrighted and is in the public domain. Canada residents can call a provincial poison control center. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. This may help ease symptoms from liver . A 2015 study in worms found that milk thistle increased resistance to oxidative stress. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. In: StatPearls. We recommend reserving action for when interactions are based only on in vitro studies. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). One of milk thistle's traditional uses is easing indigestion. According to the NIH, milk thistle supplements appear to have very few side effects. Milk thistle is also available as a tea. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Eur Endocrinol. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. We avoid using tertiary references. Medical research on milk thistle and liver health has led to mixed results. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. increased sweating. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. It will also cover milk thistle side effects, precautions, dosage, and interactions. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Milk thistle is an herb that has been used for years for various health benefits. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Cathy Wong is a nutritionist and wellness expert. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014.
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